The core of this invention is a combination of analytical and experimental methods, which allow a fast, cheap and easy way to identify different observable physiologic states in a BMP process.
It was found that a sole measurement of aspartic acid relative concentration validated by total protein measurement in the extracellular medium allows differentiating a healthy culture from a unhealthy culture. Moreover it was found that a sole measurement of the glutamic acid and alanine relative concentration allows differentiating a gas limited from a liquid limited culture. The method can be applied to new strains and cultures, after having done a specific set of experiments for method calibration controlling the desired physiologic state, validating it with advanced analytic strategies to obtain the corresponding extracellular fingerprint in terms of excretion or consumption linked to a physiologic state for the compounds of interest.
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